Professor Neeraj Saxena

MBBS, MD, MSc (Pain Management), Dip ILBM, PhD, FRCA, FFPMRCA

Consultant
Pain Management
Royal Glamorgan Hospital & Prince Charles Hospital
Cwm Taf Morgannwg University Health Board

Clinical Senior Lecturer
School of Psychology, Cardiff University

Clinical Lead
Pain Services, Royal Glamorgan Hospital/ Prince Charles Hospital

Other roles
Past Chair- Welsh Pain Society (2022- )
Chair- South Wales Network of Acute Pain teams (2018-)
Board Member- Faculty of Pain Medicine Professional Standards Committee (2021-)
Editor BJA-Education (2021-)

Past roles
Chair- Welsh Pain Society (2019-22)
Vice Chair- Welsh Pain Society (2017-19)
Hon. Secretary- South Wales Network of Acute Pain teams (2015-18)
NISCHR Clinical Research Fellow

Qualifications
Diploma IBLM/BSLM:
International Board of Lifestyle Medicine, (USA)
PhD:
Neurosciences, (Cardiff University)
FFPMRCA:
Royal College of Anaesthetists (London)
MSc : Pain Management,
Cardiff University
CCT
Royal College of Anaesthetists
FRCA:
Royal College of Anaesthetists (London)
MD: Anaesthetics, Intensive Care & Pain Medicine,
Delhi University, India
MBBS: Delhi University, India

Memberships
• British Medical Association
• British Society of Lifestyle Medicine
• British Pain Society
• International Association on the study of Pain
• Welsh Pain Society
• Indian Society of Anaesthesiologists
• MDDUS

Scientific Work (Publications)

  1. Saxena N, Muthukumaraswamy SD, Richmond L, Babic A, Singh KD, Hall JE, Wise RG, Shaw AD: A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography. Neuroimage 2021; 245: 118659
  2. Saxena N, Gili T, Diukova A, Huckle D, Hall JE, Wise RG: Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study, Proceedings of the International School on Magnetic Resonance and Brain Function – XIII Workshop. Edited by Ronen I, Bianciardi M, Giove F, Frontiers Media SA, 2021
  3. Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD: Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. Neuroimage 2020; 221: 117189
  4. Rossiter H, Chandler H, Saxena N, Wise RG, Singh KD, Khot S. Oscillatory dynamics in ischaemic pain. British Journal of Pain 2020: 2
  5. El-Mekki J, Saxena N. A service evaluation of the use of cannabidiol products among people with chronic/persistent pain, attending Cwm Taf Morgannwg University Hospitals. British Journal of Pain 2020: 1-2
  6. Varanasi M, Saxena N. Patient engagement with a pre-clinic questionnaire in outpatient pain clinics. British Journal of Pain 2020: 3
  7. Saxena N, Gili T, Diukova A, Huckle D, Hall JE, Wise RG: Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study. Frontiers in Physiology 2019; 10
  8. Patitucci E, Stickland R, Chandler H, Germuska M, Foster C, Khot S, Saxena N, Tomassini V, Wise RG: Voxel-wise CMRO2 mapping reveals focally-reduced task-related oxygen consumption in multiple sclerosis., 2019
  9. Patitucci E, Foster C, Stickland R, Chandler H, Germuska M, Khot S, Saxena N, Tomassini V, Wise RG: Energetics of brain plasticity in the healthy and MS brain: a quantitative fMRI study OHBM. Rome, 2019
  10. Patitucci E, Foster C, Stickland R, Chandler H, Germuska M, Khot S, Saxena N, Tomassini V, Wise RG: Energetics of brain plasticity in the healthy and MS brain: a quantitative fMRI study, OHBM, 2019
  11. Chandler HL, Stickland R, Germuska M, Patitucci E, Foster C, Khot S, Saxena N, Bhome-Dhaliwal S, Tomassini V, Wise RG: Quantification of cerebral grey matter vascular and metabolic functionin multiple sclerosis using dual-calibrated fMRI., ISMRM. Paris, 2019
  12. Bosanquet D, Ambler G, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Pickles T, Harris D, Milosevic S, Fitzsimmons D, Saxena N, Twine C: Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): results from a randomised controlled feasibility trial. BMJ Open 2019; 9: e029233
  13. Bosanquet DC, Ambler GK, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Harris D, Pickles T, Milosevic S, Fitzsimmons D, Saxena N, Twine CP: Major lower limb amputation audit – introduction and implementation of a multimodal perioperative pain management guideline. Br J Pain 2018; 12: 257-258
  14. Stickland R, Germuska M, Chandler H, Foster C, Saxena N, Khot S, Tomassini V, Wise RG: Visual stimulus induced changes in oxygen metabolism in Multiple Sclerosis, School of Brain Cells and Circuits: From cell physiology to integrated signals and emerging brain functions, 2017
  15. Bosanquet DC, Ambler GK, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Pickles T, Harris D, Fitzsimmons D, Saxena N, Twine CP: Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): study protocol for a randomised controlled pilot study. Trials 2017; 18: 629
  16. Saxena N, Gili T, Huckle D, Bell S, Hall J, Wise R: Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: an arterial spin labelling study. British Journal of Anaesthesia 2016; 117: e841
  17. Saxena N, Forsyth A, Babic A, Dasari S, Richmond L, Worthen S, Hall J, Muthukumaraswamy S: Dissociating analgesic and sedative actions of anaesthetic drugs with magnetoencephalography (MEG); Initial results., 16th World Congress on Pain. Yokohama, Japan, IASP, 2016, pp PTH392
  18. Saxena N, Babic A, Richmond L, Shaw A, Hall J, Muthukumaraswamy S: Visual stimulus-induced oscillatory activity can differentiate between GABAergic and non-GABAergic sedation. British Journal of Anaesthesia 2016; 11: e841- e842
  19. Shaw AD, Saxena N, L EJ, Hall JE, Singh KD, Muthukumaraswamy SD: Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. Eur Neuropsychopharmacol 2015; 25: 1136-46
  20. Richmond L, Jackson L, Shaw A, Hall J, Saxena N, Muthukumaraswamy S: The neural, oscillatory, correlates of sedative ketamine infusion: a pharmaco-MEG (magnetoencephalographic) study. European Journal of Anaesthesiology 2015; 32: 183
  21. Muthukumaraswamy SD, Shaw AD, Jackson LE, Hall J, Moran R, Saxena N: Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans. J Neurosci 2015; 35: 11694-706
  22. Warnert EA, Harris AD, Murphy K, Saxena N, Tailor N, Jenkins NS, Hall JE, Wise RG: In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study. J Cereb Blood Flow Metab 2014; 34: 956-63
  23. Muthukumaraswamy S, Jackson LE, Saxena N, Shaw A, Wise R, Hall JE: Investigating glutamatergic neuro-transmission in the human brain using ketamine sedation. British Journal of Anaesthesia 2014; 113: 328-329P
  24. Clark J, Short A, Chawathe M, Francis J, Saxena N, Bogod D, Girotra V: Development of a realistic epidural simulator – a translational research project. Anaesthesia 2014; 69: 17
  25. Saxena N, Muthukumaraswamy SD, Diukova A, Singh K, Hall J, Wise R: Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation. PLoS One 2013; 8: e57685
  26. Saxena N: Airway management plan in patients with difficult airways having regional anesthesia. J Anaesthesiol Clin Pharmacol 2013; 29: 558-60
  27. Harris AD, Murphy K, Diaz CM, Saxena N, Hall JE, Liu TT, Wise RG: Cerebral blood flow response to acute hypoxic hypoxia. NMR Biomed 2013
  28. Gili T, Saxena N, Diukova A, Murphy K, Hall JE, Wise RG: The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation. J Neurosci 2013; 33: 4024-31
  29. Saxena N, Muthukumaraswamy S, Diukova A, Wilkes A, Singh KD, Wise RG, Hall JE: Alterations of stimulus-induced gamma oscillatory activity during propofol sedation. , Anaesthetic Reasearch Society. London, British Journal of Anaesthesia, 2012, pp 870P – 871P
  30. Saxena N, Kumar M, Tailor N, Wilkes T, Hodzovic I: Comparing performance of three non-rebreathing Oxygen masks – Topout, Intersurgical™ and Flexicare™. A randomised, cross-over volunteer study. . British Journal of Anaesthesia 2012; 109: 665-666P
  31. Saxena N, Kadambande S, Khot S: From presentation to journal publication: the journey of our Society’s ASM abstracts. . Pain News 2012; 10: 49-52
  32. Saxena N, Jeffs S, Hughes O: Do Pain Management Programmes lead to permanent changes? Long-term effectiveness of an outpatient interdisciplinary PMP: an observational study. , World Congress on Pain. Milan, IASP, 2012
  33. Saxena N, Diukova A, Venzi M, Gili T, Huckle D, Bell S, Wise RG, Hall JE: Endogenous brain oscillations during sedation: initial results of a magnetoencephalography and functional magnetic resonance imaging study. British Journal of Anaesthesia 2012; 108: 721P
  34. Kumar M, Saxena N, Wilkes T, Hodzovic I: Evaluation of three non-rebreathing Oxygen delivery masks. British Journal of Anaesthesia 2012; 109: 660P
  35. Khurana A, Guha A, Saxena N, Pugh S, Ahuja S: Comparison of aprotinin and tranexamic acid in adult scoliosis correction surgery. Eur Spine J 2012
  36. Harris AD, Roberton VH, Huckle DL, Saxena N, Evans CJ, Murphy K, Hall JE, Bailey DM, Mitsis G, Edden RA, Wise RG: Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia. J Magn Reson Imaging 2012
  37. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Mild sedation alters eigenvector centrality of BOLD FMRI in the thalamus and brainstem OHBM Proceedings 2012
  38. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Physiological noise correction may help to detect changes in brain activity during mild sedation. . OHBM Proceedings 2012
  39. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Mapping alterations in cortical and subcortical functional connectivity induced by light sedation. . OHBM Proceedings 2012
  40. Saxena N, Lewis E: Anaesthetic interventions for vaginal twin deliveries; role of epidural analgesia. International Journal of Obstetric Anaesthesia 2010: S42
  41. Edden RA, Harris AD, Murphy K, Evans CJ, Saxena N, Hall JE, Bailey DM, Wise RG: Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. J Magn Reson Imaging 2010; 32: 320-5
  42. Saxena N, Parry-Jones AJ: Traumatic haemorrhage into an occult phaeochromocytoma: presentation and management in a patient with septic shock. Anaesthesia 2008; 63: 428-32
  43. Saxena N, Greenway I, Harding LJ, Davies NG: A complication of the ‘atraumatic inserter’ of the Tracoe experc percutaneous dilation tracheostomy set. Anaesthesia 2008; 63: 1377-9
  44. Kumar M, Saxena N, Saxena A: The effect of a colloid or crystalloid preload on hypotension caused by induction of anaesthesia with propofol and fentanyl. . Journal of Anaesthesiology Clinical Pharmacology 2008; 24: 409-412
  45. Khot S, Taylor A, Saxena N, Knox G: Chronic low back pain: What doctors think?, British Pain Society- Annual Scientif Meeting, British Pain Society, 2007
  46. Saxena N, Sharma M: Cerebral infarction following carotid arterial injection of adrenaline. Can J Anaesth 2005; 52: 119
  47. Saxena N, Chaudhary S: Open indirect cardiac massage in a neonate. Indian J Pediatr 2005; 72: 253-5
  48. Saxena AK, Saxena N, Aggarwal B, Sethi AK: An unusual complication of sinus arrest following right-sided stellate ganglion block: a case report. Pain Pract 2004; 4: 245-8
  49. Saxena N, Ahuja S: Laryngeal mask cuff damage during interscalene block. Anaesthesia 2003; 58: 600
  50. Saxena N, Sharma M, Mishra KK, Kumar A: Comparative evaluation of the effect of glycopyrrolate with thiopentone or propofol, for modified ECT on cardiovascular parameters and seizure characteristics., ISA-GOLDCON. Coimbatore, 2002