Scientific Work (Publications)

1. Saxena N, Shaw A, Muthukumaraswamy S, Wise R, Singh KD: Robust resting-state oscillatory fingerprints of GABA-ergic and non-GABA-ergic sedation, BIOMAG 2022. Birmingham, U.K., 2022, pp 454
2. Chiarelli AM, Germuska M, Chandler H, Stickland R, Patitucci E, Biondetti E, Mascali D, Saxena N, Khot S, Steventon J, Foster C, Rodriguez-Soto AE, Englund E, Murphy K, Tomassini V, Wehrli FW, Wise RG: A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. J Cereb Blood Flow Metab 2022; 42: 1192-1209
3. Chandler HL, Stickland RC, Patitucci E, Germuska M, Chiarelli AM, Foster C, Bhome-Dhaliwal S, Lancaster TM, Saxena N, Khot S, Tomassini V, Wise RG: Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI. J Cereb Blood Flow Metab 2022: 271678X221121849
4. Chiarelli AM, Germuska M, Chandler H, Stickland R, Patitucci E, Biondetti E, Mascali D, Saxena N, Khot S, Steventon J, Foster C, Rodriguez-Soto AE, Englund E, Murphy K, Tomassini V, Wehrli FW, Wise RG: Oxygen Transport Modelling for Mapping Brain Oxygen Extraction Fraction with Single Gas Calibrated fMRI, Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting. London, 2022
5. Saxena N, Muthukumaraswamy SD, Richmond L, Babic A, Singh KD, Hall JE, Wise RG, Shaw AD: A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography. Neuroimage 2021; 245: 118659
6. Saxena N, Gili T, Diukova A, Huckle D, Hall JE, Wise RG: Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study, Proceedings of the International School on Magnetic Resonance and Brain Function – XIII Workshop. Edited by Ronen I, Bianciardi M, Giove F, Frontiers Media SA, 2021
7. Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD: Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. Neuroimage 2020; 221: 117189
8. Rossiter H, Chandler H, Saxena N, Wise RG, Singh KD, Khot S. Oscillatory dynamics in ischaemic pain. British Journal of Pain 2020: 2
9. El-Mekki J, Saxena N. A service evaluation of the use of cannabidiol products among people with chronic/persistent pain, attending Cwm Taf Morgannwg University Hospitals. British Journal of Pain 2020: 1-2
10. Varanasi M, Saxena N. Patient engagement with a pre-clinic questionnaire in outpatient pain clinics. British Journal of Pain 2020: 3
11. Saxena N, Gili T, Diukova A, Huckle D, Hall JE, Wise RG: Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study. Frontiers in Physiology 2019; 10
12. Patitucci E, Stickland R, Chandler H, Germuska M, Foster C, Khot S, Saxena N, Tomassini V, Wise RG: Voxel-wise CMRO2 mapping reveals focally-reduced task-related oxygen consumption in multiple sclerosis., 2019
13. Patitucci E, Foster C, Stickland R, Chandler H, Germuska M, Khot S, Saxena N, Tomassini V, Wise RG: Energetics of brain plasticity in the healthy and MS brain: a quantitative fMRI study OHBM. Rome, 2019
14. Patitucci E, Foster C, Stickland R, Chandler H, Germuska M, Khot S, Saxena N, Tomassini V, Wise RG: Energetics of brain plasticity in the healthy and MS brain: a quantitative fMRI study, OHBM, 2019
15. Chandler HL, Stickland R, Germuska M, Patitucci E, Foster C, Khot S, Saxena N, Bhome-Dhaliwal S, Tomassini V, Wise RG: Quantification of cerebral grey matter vascular and metabolic functionin multiple sclerosis using dual-calibrated fMRI., ISMRM. Paris, 2019
16. Bosanquet D, Ambler G, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Pickles T, Harris D, Milosevic S, Fitzsimmons D, Saxena N, Twine C: Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): results from a randomised controlled feasibility trial. BMJ Open 2019; 9: e029233
17. Bosanquet DC, Ambler GK, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Harris D, Pickles T, Milosevic S, Fitzsimmons D, Saxena N, Twine CP: Major lower limb amputation audit – introduction and implementation of a multimodal perioperative pain management guideline. Br J Pain 2018; 12: 257-258
18. Stickland R, Germuska M, Chandler H, Foster C, Saxena N, Khot S, Tomassini V, Wise RG: Visual stimulus induced changes in oxygen metabolism in Multiple Sclerosis, School of Brain Cells and Circuits: From cell physiology to integrated signals and emerging brain functions, 2017
19. Bosanquet DC, Ambler GK, Waldron CA, Thomas-Jones E, Brookes-Howell L, Kelson M, Pickles T, Harris D, Fitzsimmons D, Saxena N, Twine CP: Perineural local anaesthetic catheter after major lower limb amputation trial (PLACEMENT): study protocol for a randomised controlled pilot study. Trials 2017; 18: 629
20. Saxena N, Gili T, Huckle D, Bell S, Hall J, Wise R: Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: an arterial spin labelling study. British Journal of Anaesthesia 2016; 117: e841
21. Saxena N, Forsyth A, Babic A, Dasari S, Richmond L, Worthen S, Hall J, Muthukumaraswamy S: Dissociating analgesic and sedative actions of anaesthetic drugs with magnetoencephalography (MEG); Initial results., 16th World Congress on Pain. Yokohama, Japan, IASP, 2016, pp PTH392
22. Saxena N, Babic A, Richmond L, Shaw A, Hall J, Muthukumaraswamy S: Visual stimulus-induced oscillatory activity can differentiate between GABAergic and non-GABAergic sedation. British Journal of Anaesthesia 2016; 11: e841- e842
23. Shaw AD, Saxena N, L EJ, Hall JE, Singh KD, Muthukumaraswamy SD: Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. Eur Neuropsychopharmacol 2015; 25: 1136-46
24. Richmond L, Jackson L, Shaw A, Hall J, Saxena N, Muthukumaraswamy S: The neural, oscillatory, correlates of sedative ketamine infusion: a pharmaco-MEG (magnetoencephalographic) study. European Journal of Anaesthesiology 2015; 32: 183
25. Muthukumaraswamy SD, Shaw AD, Jackson LE, Hall J, Moran R, Saxena N: Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans. J Neurosci 2015; 35: 11694-706
26. Warnert EA, Harris AD, Murphy K, Saxena N, Tailor N, Jenkins NS, Hall JE, Wise RG: In vivo assessment of human brainstem cerebrovascular function: a multi-inversion time pulsed arterial spin labelling study. J Cereb Blood Flow Metab 2014; 34: 956-63
27. Muthukumaraswamy S, Jackson LE, Saxena N, Shaw A, Wise R, Hall JE: Investigating glutamatergic neuro-transmission in the human brain using ketamine sedation. British Journal of Anaesthesia 2014; 113: 328-329P
28. Clark J, Short A, Chawathe M, Francis J, Saxena N, Bogod D, Girotra V: Development of a realistic epidural simulator – a translational research project. Anaesthesia 2014; 69: 17
29. Saxena N, Muthukumaraswamy SD, Diukova A, Singh K, Hall J, Wise R: Enhanced Stimulus-Induced Gamma Activity in Humans during Propofol-Induced Sedation. PLoS One 2013; 8: e57685
30. Saxena N: Airway management plan in patients with difficult airways having regional anesthesia. J Anaesthesiol Clin Pharmacol 2013; 29: 558-60
31. Harris AD, Murphy K, Diaz CM, Saxena N, Hall JE, Liu TT, Wise RG: Cerebral blood flow response to acute hypoxic hypoxia. NMR Biomed 2013
32. Gili T, Saxena N, Diukova A, Murphy K, Hall JE, Wise RG: The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation. J Neurosci 2013; 33: 4024-31
33. Saxena N, Muthukumaraswamy S, Diukova A, Wilkes A, Singh KD, Wise RG, Hall JE: Alterations of stimulus-induced gamma oscillatory activity during propofol sedation. , Anaesthetic Reasearch Society. London, British Journal of Anaesthesia, 2012, pp 870P – 871P
34. Saxena N, Kumar M, Tailor N, Wilkes T, Hodzovic I: Comparing performance of three non-rebreathing Oxygen masks – Topout, Intersurgical™ and Flexicare™. A randomised, cross-over volunteer study. . British Journal of Anaesthesia 2012; 109: 665-666P
35. Saxena N, Kadambande S, Khot S: From presentation to journal publication: the journey of our Society’s ASM abstracts. . Pain News 2012; 10: 49-52
36. Saxena N, Jeffs S, Hughes O: Do Pain Management Programmes lead to permanent changes? Long-term effectiveness of an outpatient interdisciplinary PMP: an observational study. , World Congress on Pain. Milan, IASP, 2012
37. Saxena N, Diukova A, Venzi M, Gili T, Huckle D, Bell S, Wise RG, Hall JE: Endogenous brain oscillations during sedation: initial results of a magnetoencephalography and functional magnetic resonance imaging study. British Journal of Anaesthesia 2012; 108: 721P
38. Kumar M, Saxena N, Wilkes T, Hodzovic I: Evaluation of three non-rebreathing Oxygen delivery masks. British Journal of Anaesthesia 2012; 109: 660P
39. Khurana A, Guha A, Saxena N, Pugh S, Ahuja S: Comparison of aprotinin and tranexamic acid in adult scoliosis correction surgery. Eur Spine J 2012
40. Harris AD, Roberton VH, Huckle DL, Saxena N, Evans CJ, Murphy K, Hall JE, Bailey DM, Mitsis G, Edden RA, Wise RG: Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia. J Magn Reson Imaging 2012
41. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Mild sedation alters eigenvector centrality of BOLD FMRI in the thalamus and brainstem OHBM Proceedings 2012
42. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Physiological noise correction may help to detect changes in brain activity during mild sedation. . OHBM Proceedings 2012
43. Gili T, Saxena N, Diukova A, Murphy K, Hall J, Wise R: Mapping alterations in cortical and subcortical functional connectivity induced by light sedation. . OHBM Proceedings 2012
44. Saxena N, Lewis E: Anaesthetic interventions for vaginal twin deliveries; role of epidural analgesia. International Journal of Obstetric Anaesthesia 2010: S42
45. Edden RA, Harris AD, Murphy K, Evans CJ, Saxena N, Hall JE, Bailey DM, Wise RG: Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. J Magn Reson Imaging 2010; 32: 320-5
46. Saxena N, Parry-Jones AJ: Traumatic haemorrhage into an occult phaeochromocytoma: presentation and management in a patient with septic shock. Anaesthesia 2008; 63: 428-32
47. Saxena N, Greenway I, Harding LJ, Davies NG: A complication of the ‘atraumatic inserter’ of the Tracoe experc percutaneous dilation tracheostomy set. Anaesthesia 2008; 63: 1377-9
48. Kumar M, Saxena N, Saxena A: The effect of a colloid or crystalloid preload on hypotension caused by induction of anaesthesia with propofol and fentanyl. . Journal of Anaesthesiology Clinical Pharmacology 2008; 24: 409-412
49. Khot S, Taylor A, Saxena N, Knox G: Chronic low back pain: What doctors think?, British Pain Society- Annual Scientif Meeting, British Pain Society, 2007
50. Saxena N, Sharma M: Cerebral infarction following carotid arterial injection of adrenaline. Can J Anaesth 2005; 52: 119
51. Saxena N, Chaudhary S: Open indirect cardiac massage in a neonate. Indian J Pediatr 2005; 72: 253-5
52. Saxena AK, Saxena N, Aggarwal B, Sethi AK: An unusual complication of sinus arrest following right-sided stellate ganglion block: a case report. Pain Pract 2004; 4: 245-8
53. Saxena N, Ahuja S: Laryngeal mask cuff damage during interscalene block. Anaesthesia 2003; 58: 600
54. Saxena N, Sharma M, Mishra KK, Kumar A: Comparative evaluation of the effect of glycopyrrolate with thiopentone or propofol, for modified ECT on cardiovascular parameters and seizure characteristics., ISA-GOLDCON. Coimbatore, 2002